Blood perfusion in osteomyelitis studied with [15O]water PET in a juvenile porcine model

EJNMMI Research

Table 1 Data for pigs

Pig no.^a	Weight (kg)^b	Days from inoculation until scanning	Activity injected for [¹⁵O]water PET (MBq)
1	40	7	500
2	40	7	1000
3^c	39	7	1000
4	42	7	850
5	20	14	950
6	22	7	832
7	23	7	956
8	21	8	1000
9	23	8	1000
10	22.5	7	1000
11	19	7	500

^aConsecutive numbering of PET scanned pigs. Physiological data for pigs no. 1–4 have been described in [20] and for pigs no. 6–10 in [19]. Pig no. 5 was scanned 14 days after inoculation in an attempt to study more chronic infections, but this extended infection period was difficult to pursue because the pigs reached the approved humane endpoint
^bBody weight was changed from approx 40 to 20 kg as part of the refinement of the porcine osteomyelitis model [40]. Shortly, our refinement study showed that fewer pigs had to be killed due to humane endpoints when smaller pigs were used and when they were treated with penicillin just after onset of the first clinical symptoms of lameness
^cInfection did not catch in pig no. 3, but the pig is retained for the comparison of right and left hind limbs in uninfected tissue (see main text)