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Table 2 Mean absorbed dose calculations of 177Lu-octreotate in GOT1-bearing nude mice

From: Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

Tissue Mean absorbed dose per administered activity (Gy/MBq)
With priming, (5+) 10 MBq Without priming, 15 MBq
Adrenals 0.11 0.079
Blood 0.00067 0.00069
Kidneys 0.25 0.32
Liver 0.014 0.011
Lungs 0.069 0.038
Pancreas 0.042 0.024
Spleen 0.023 0.012
Tumor 0.51 0.27a
  1. The mean absorbed dose per administered activity after 10 or 15 MBq 177Lu-octreotate (Gy/MBq) (with and without priming, n = 9/group), respectively. Values for the 5 + 10 MBq group were estimated from the values for the 10 MBq administrations only
  2. a n = 8