A | 177Lu activity concentration (%IA/g) | ||||||||
With priming, (5+) 10 MBq (n = 9) | Without priming, 15 MBq (n = 8) | ||||||||
Tissue | 24 h | 72 h | 168 h | 24 h | 72 h | 168 h | |||
Adrenals | 1.4 (0.1)a | 0.42 (0.20)a | 0.36 (0.06) | 0.60 (0.03)a | 1.4 (0.1)a | 0.30 (0.06) | |||
Blood | 0.013 (0.001) | 0.0048 (0.0005) | 0.0017 (0.0004) | 0.011 (0.001) | 0.0055 (0.0002) | 0.0021 (0.0002) | |||
Kidneys | 4.5 (0.8) | 1.5 (0.1) | 0.71 (0.14)a | 6.8 (0.3) | 2.3 (0.4) | 0.50 (0.04)a | |||
Liver | 0.094 (0.008) | 0.077 (0.009) | 0.070 (0.009) | 0.12 (0.06) | 0.10 (0.01) | 0.049 (0.004) | |||
Lungs | 0.84 (0.10)a | 0.43 (0.03) | 0.31 (0.02)a | 0.48 (0.04)a | 0.33 (0.02) | 0.15 (0.003)a | |||
Pancreas | 0.54 (0.02)a | 0.30 (0.02) | 0.18 (0.02)a | 0.36 (0.03)a | 0.26 (0.04) | 0.062 (0.011)a | |||
Spleen | 0.080 (0.010) | 0.090 (0.006) | 0.090 (0.010) | 0.10 (0.01) | 0.088 (0.009) | 0.061 (0.005) | |||
Tumor | 2.5 (0.9) | 4.6 (0.8)a | 1.8 (0.5) | 1.6 (0.1) | 1.6 (0.2)a,b | 0.84 (0.31) | |||
B | Tumor-to-normal tissue activity concentration ratio (T/N) | ||||||||
With priming, (5+) 10 MBq (n = 9) | Without priming, 15 MBq (n = 8) | ||||||||
Tissue | 24 h | 72 h | 168 h | 24 h | 72 h | 168 h | |||
Adrenals | 1.7 (0.5) | 23 (9) | 4.6 (1.2) | 2.7 (0.4) | 1.1 (0.1) | 3.8 (1.6) | |||
Blood | 190 (62) | 1100 (280) | 1100 (360) | 160 (34) | 290 (21) | 420 (160) | |||
Kidneys | 0.62 (0.29) | 3.1 (0.7)a | 2.6 (0.8) | 0.23 (0.02) | 0.76 (0.19)a | 1.5 (0.6) | |||
Liver | 27 (10) | 63 (14) | 24 (5) | 14 (1) | 17 (2) | 16 (6) | |||
Lungs | 2.9 (1.1) | 10 (2) | 5.4 (1.3) | 3.4 (0.4) | 4.9 (0.6) | 5.8 (2.2) | |||
Pancreas | 4.5 (1.5) | 15 (2)a | 10 (3) | 4.4 (0.3) | 6.6 (1.1)a | 12 (4) | |||
Spleen | 32 (13) | 53 (11) | 18 (4) | 17 (1) | 19 (3) | 13 (5) | |||
C | Tumor cell proliferation assed by Ki67 staining (%) | ||||||||
With priming, (5+) 10 MBq (n = 9) | Without priming, 15 MBq (n = 8) | Controls | |||||||
Antibody | 24 h | 72 h | 168 h | 24 h | 72 h | 168 h | 24 h | 72 h | 168 h |
Ki67 | 27 (4) | 22 (2)c | 25 (2)c | 31 (1)c | 29 (3)b | 28 (2)c | 45 (1)b | 42 (1)b | 42 (2)b |