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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

Fig. 5

Expression of genes associated with cell death. Differential expression of genes associated with apoptotic cell death (a pro-apoptotic genes, b anti-apoptotic genes, c general apoptosis-related genes) in tumor samples from animals treated with 15 or 5 + 10 MBq 177Lu-octreotate, compared with untreated controls after 24 h, 72 h, and 41 days after the last injection. No genes related to non-apoptotic cell death were found in the analysis, and no genes associated with apoptotic cell death were found at 168 h after injection. Transcripts with changed expression ≥1.5-fold and an adjusted p < 0.01 were considered significantly regulated; association to biological process was performed using the GO database with a p value cutoff of <0.05

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