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Table 1 Effect on survival of TNF sensitive L929s cells following exposure to 300 U/ml human TNF and various test solutions of TNF blocking agents in the presence of 1 μg/ml Actinomycin D

From: 99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study

  Mean % cell survival (SD)
Tested TNF blockers at 3 concentrations 99mTc-S-HYNIC CZP S-HYNIC CZP CZP Infliximab
Control (no TNF blocker) 0.0 (0.0) 0.0 (0.0) 0.0 (0.0) 0.0 (0.0)
250 ng/ml 109.1 (2.6) 111.9 (0.5) 81.8 (1.5) 81.1 (3.9)
50 ng/ml 113.8 (4.2) 111.0 (2.2) 96.1 (23.2) 57.4 (1.4)
10 ng/ml 115.2 (0.6) 88.5 (0.3) 56.6 (2.8) 5.2 (0.0)