Table 1 Effect on survival of TNF sensitive L929s cells following exposure to 300 U/ml human TNF and various test solutions of TNF blocking agents in the presence of 1 μg/ml Actinomycin D
Mean % cell survival (SD) | ||||
|---|---|---|---|---|
Tested TNF blockers at 3 concentrations | 99mTc-S-HYNIC CZP | S-HYNIC CZP | CZP | Infliximab |
Control (no TNF blocker) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) |
250 ng/ml | 109.1 (2.6) | 111.9 (0.5) | 81.8 (1.5) | 81.1 (3.9) |
50 ng/ml | 113.8 (4.2) | 111.0 (2.2) | 96.1 (23.2) | 57.4 (1.4) |
10 ng/ml | 115.2 (0.6) | 88.5 (0.3) | 56.6 (2.8) | 5.2 (0.0) |