Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, 18F-labeled [Nle14,Lys40]exendin-4 analog, shows promise for clinical imaging

EJNMMI Research

Table 1 Ex vivo biodistribution of [¹⁸F]exendin-4 in rat

Differences between values at 60-min and 60-min blocking were determined with the Student t test without correction for multiple comparisons. One-way ANOVA and Bonferroni’s multiple comparison test was used to determine the differences at 60, 120, 240, and 360 min. */^† P < 0.05, **/^†† P < 0.01, and ***/^††† P < 0.001 statistically significant compared to [¹⁸F]exendin-4 at 60 min post injection. Results are expressed as the mean ± SD percentage of the injected dose per gram of tissue