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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, 18F-labeled [Nle14,Lys40]exendin-4 analog, shows promise for clinical imaging

Fig. 5

Ex vivo [18F]exendin-4 uptake in rat pancreas and pancreatic islets. a Tracer uptake in islets was clearly visible at 60 min p.i. Uptake in islets was verified by staining the same section with insulin antibody (upper right inset and lower right inset). b–c Tracer specificity was assessed by co-injecting [18F]exendin-4 and excess cold exendin-3. d Towards longer time points, the high ratios indicated a significant difference in islet labeling compared to background (N = 2–8 rats/time point). a–c Scale bars 2000 μm

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