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Fig. 3 | EJNMMI Research

Fig. 3

From: Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, 18F-labeled [Nle14,Lys40]exendin-4 analog, shows promise for clinical imaging

Fig. 3

Ex vivo measurements of accumulation of exendin-based PET and SPECT tracers in rat kidney. The renal clearance of [18F]exendin-4 (blue) was rapid, and the radioactivity in kidney was significantly lower at all investigated time points, compared to other, metal-labeled, exendin-based tracers designed for PET and SPECT analyses [2, 3, 41]. Ex vivo autoradiography images (blue inset) show the decreasing [18F]exendin-4 accumulation in the kidney cortex at 60, 120, and 360 min p.i.

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