Fig. 2

Effects of rotenone on time activity curves (TACs) (a) and uptake of ¹⁸F-BCPP-BF at early (b) and late (c) phases by the liver and kidney of the control rat. Vehicle or rotenone (0.1 mg/kg) was continuously infused into the control rats through the tail vein for 1 h, followed by the ¹⁸F-BCPP-BF injection into rats through the tail vein. PET scanning was conducted as described in the legend of Fig. 1. The volumes of interest (VOIs) were set on the kidney (renal cortex and pelvis) and liver, and TACs were obtained in each organ as SUV (a). Averaged SUV values from 15 to 30 min (b) and from 70 to 90 min (c) after the ¹⁸F-BCPP-BF injection were calculated from the data of time activity curves. *p < 0.05 vs. vehicle