Skip to main content

Table 2 Normalised cumulative activity (NCA) for organs and tissues of significant uptake

From: The clinical safety, biodistribution and internal radiation dosimetry of [18F]AH113804 in healthy adult volunteers

Source region r S

\( {\tilde{A}}_{r_{\mathrm{S}}}^{\mathrm{Norm}}\kern0.24em \left(\raisebox{1ex}{$ MBq h$}\!\left/ \!\raisebox{-1ex}{$ MBq$}\right.\right) \)

Subject

Mean

001–0011

001–0012

001–0013

001–0014

001–0015

001–0016

Sex

M

F

M

M

M

F

M

F

Brain

1.02E−02

8.37E−03

1.02E−02

1.05E−02

8.29E−03

7.26E−03

9.78E−03

7.81E−03

Gallbladder

2.19E−03

5.74E−04

2.20E−03

2.84E−03

1.71E−03

5.53E−04

2.23E−03

5.64E−04

Heart contents

2.87E−02

2.27E−02

3.41E−02

3.10E−02

2.78E−02

2.53E−02

3.04E−02

2.40E−02

Heart wall

8.38E−03

1.67E−02

4.11E−03

6.37E−03

2.67E−03

1.37E−02

5.38E−03

1.52E−02

Kidneys

4.13E−02

1.28E−01

4.92E−02

5.04E−02

5.97E−02

6.24E−02

5.02E−02

9.52E−02

Liver

1.29E−01

1.27E−01

1.74E−01

1.24E−01

1.09E−01

1.11E−01

1.34E−01

1.19E−01

Lungs

5.99E−02

3.95E−02

5.05E−02

6.16E−02

5.62E−02

5.25E−02

5.71E−02

4.60E−02

Intestinal contents

Small intestine

2.20E−03

0.00E+00

6.35E−04

0.00E+00

3.73E−03

2.70E−03

1.64E−03

1.35E−03

Bolus (unitless)

3.53E−03

0.00E+00

1.07E−03

0.00E+00

6.95E−03

5.38E−03

2.89E−03

2.69E−03

Spleen

1.78E−02

1.62E−02

1.66E−02

1.38E−02

2.00E−02

1.43E−02

1.71E−02

1.52E−02

Thyroid

6.61E−04

5.35E−04

9.35E−04

1.07E−03

6.17E−04

8.55E−04

8.20E−04

6.95E−04

Urinary bladder contents

Fit

1.14E+00

1.09E+00

8.87E−01

9.13E−01

1.14E+00

1.15E+00

1.02E+00

1.12E+00

Dynamic model (3.5-h voiding interval)

5.94E−01

6.15E−01

5.00E−01

5.29E−01

6.41E−01

6.52E−01

5.66E−01

6.34E−01

Remaining tissues

1.20E+00

1.23E+00

1.32E+00

1.43E+00

1.25E+00

1.12E+00

1.30E+00

1.17E+00

  1. The ‘Bolus’ value for the intestinal contents is the maximum decay-corrected fraction of injected activity encompassed by the intestinal VOI and is input to the ICRP 30 model within the OLINDA/EXM software