The cingulate island sign within early Alzheimer’s disease-specific hypoperfusion volumes of interest is useful for differentiating Alzheimer’s disease from dementia with Lewy bodies

EJNMMI Research

Table 1 Demographic data

	AD	DLB
Age at the time of SPECT	74.4 ± 8.5	73.9 ± 6.8
Male/female	5/12	10/8
Disease duration at the time of SPECT (years)	2.0 ± 1.6	4.0 ± 2.3**
MMSE	21.5 ± 3.3	19.1 ± 6.7
Cerebral blood flow (mean; mL/100 g/min)	39.79 ± 3.22	36.86 ± 4.16*
Heart-to-mediastrum ratio in [¹²³I]MIBG (3 h after injection)	NA	1.33 ± 0.14 (range 1.09–1.62)

AD Alzheimer’s disease, DLB dementia with Lewy bodies, SPECT single-photon emission computed tomography, MMSE Mini-Mental State Examination, [ ¹²³ I]MIBG [¹²³I]metaiodobenzylguanidine, NA not applicable
*p = 0.0200; **p = 0.0027