Grade | Overview | Glomeruli | Tubules |
---|---|---|---|
Mild | More or less normal aspect | Apoptosis of endothelium cells | Apoptotic cells |
High glomerular cell count | Inflammatory infiltrate | Rough protein staining | |
Little dilation | |||
Normal basal membrane | |||
No proteine cylinders | |||
Moderate | Tubular dilation | Same as grade 1 | More apoptotic cells |
Tubular cell damage | More pronounced dilation | ||
Thickened basal membrane | |||
Little tubular protein cylinders | |||
Regenerating cells (mitotic activity) | |||
Pronounced | Stronger tubular dilation | Smaller vascular lumina, few erythrocytes | Flat epithelium |
Cell-rich infiltrate | Partly, complete loss of epithelium | ||
Regenerating tubules | Stronger dilation | ||
Inflammatory infiltrate | |||
Regeneration present | |||
More thickened basal membrane | |||
Severe | Severe tubular dilation | Same as grade 3 | Same as grade 3, but more empty cylinders |
More optical empty space due to glomerular shrinkage | Peripheral fibrosis |