The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models

Heinzmann, Kathrin; Honess, Davina Jean; Lewis, David Yestin; Smith, Donna-Michelle; Cawthorne, Christopher; Keen, Heather; Heskamp, Sandra; Schelhaas, Sonja; Witney, Timothy Howard; Soloviev, Dmitry; Williams, Kaye Janine; Jacobs, Andreas Hans; Aboagye, Eric Ofori; Griffiths, John Richard; Brindle, Kevin Michael

doi:10.1186/s13550-016-0218-3

EJNMMI Research

Table 1 Tumour models

From: The relationship between endogenous thymidine concentrations and [¹⁸F]FLT uptake in a range of preclinical tumour models

	Tumour	Type	Origin	Model type	Host (supplier)
CRUK Cambridge Institute (CI)	AsPC-1	Pancreatic	Human	Xenograft^a	CB17 SCID mouse (Charles River)
	MiaPaCa-2	Pancreatic	Human	Xenograft^a	CB17 SCID mouse (Charles River)
	PancTu I	Pancreatic	Human	Xenograft^a	CB17 SCID mouse (Charles River)
	Colo-357	Pancreatic	Human	Xenograft^a	CB17 SCID mouse (Charles River)
	K8484^b	Pancreatic	Murine	Syngeneic allograft^a	PC mouse (p53^R172H; Pdx1-Cre) (CI)
	KPC^c	Pancreatic	Murine	Spontaneous^d	KPC mouse (Kras^G12D; p53^R172H; Pdx1-Cre) (CI)
AstraZeneca (AZ)	PC9	NSCLC	Human	Xenograft^a	CB17 SCID mouse (AstraZeneca)
	A431	Squamous carcinoma	Human	Xenograft^a	ONU mouse (AstraZeneca)
	H1975	NSCLC	Human	Xenograft^a	ONU mouse (AstraZeneca)
Imperial College London (IC)	HCT116	Colorectal	Human	Xenograft^a	BALB/c nu mouse (Charles River)
WWU Münster	A549	NSCLC	Human	Xenograft^a	NMRI nu mouse (Janvier)
	HTB56	NSCLC	Human	Xenograft^a	NMRI nu mouse (Janvier)
	EBC1	NSCLC	Human	Xenograft^a	NMRI nu mouse (Janvier)
	H1975	NSCLC	Human	Xenograft^a	NMRI nu mouse (Janvier)
WMIC Manchester	MDA-MB-231-MFP	Breast	Human	Xenograft^e	CBA nu/nu mouse (University of Manchester)
	A549	NSCLC	Human	Xenograft^a	CBA nu/nu mouse (University of Manchester)
	HCT116	Colorectal	Human	Xenograft^a	CBA nu/nu mouse (University of Manchester)
	A2870	Ovarian carcinoma	Human	Xenograft^a	CBA nu/nu mouse (University of Manchester)
	U87	Glioblastoma	Human	Xenograft^a	CBA nu/nu mouse (University of Manchester)
	FTC113	Follicular thyroid carcinoma	Human	Xenograft^a	CBA nu/nu mouse (University of Manchester)
	KHT	Sarcoma	Murine	Syngeneic autograft^a	C3H mouse (University of Manchester)
Radboudumc Nijmegen	CC531	Colorectal	Rodent	Syngeneic liver metastasis^f	Wag/Rij rats (Charles River)

^aSubcutaneous tumours
^b[15]
^cHingorani SR, Wang L, Multani AS, Combs C, Deramoudt TB, Hruban RH et al. Trp53R172H and KRASG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer cell. 2005;7(5):469–483
^dSpontaneous tumours arising in the pancreas
^eOrthotopic tumours (mammary fat-pad implant)
^fTumours created by intra-hepatic injection

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