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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake

Fig. 5

PET images, summed 30–60 min, and TACs from a Balbc nu/nu mouse (prone) bearing tumors (white arrows): a one A431 xenograft (1 × 107 cells, 15 days) or b two A431 xenografts (left: 1 × 107 cells, 28 days; right: 1 × 107 cells, 25 days). Comparison A shows a 7-times higher uptake with targeting [methyl-11C]-ZEGFR:2377-ST-CH3 compared to the non-targeting [methyl-11C]-ZTaq:3638-ST-CH3. Comparison B illustrates uptake of the targeting Affibody increasing as the tumors grow from time from inoculation

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