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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients

Fig. 2

Optimal sulfur colloid SPECT/CT uptake threshold region-of-interest definition for liver imaging parameter prediction of clinical liver function defined by Childs-Turcotte-Pugh A versus B/C class. a The receiver operator characteristic (ROC) area under the curve (AUC) is plotted versus the percentage maximum sulfur colloid SPECT uptake threshold used to define three imaging metrics: functional liver volume (FLV) ratio of total liver volume, mean liver-to-spleen (L/S) uptake ratio, and their product as the total liver function (TLF) ratio. b ROC curves at the optimal SC SPECT threshold for FLV ratio, L/S mean ratio, and TLF ratios. The product of liver function magnitude and volume yields the highest accuracy for CTP classification, with a TLF cutoff value of 0.35 having a sensitivity of 0.88 and specificity of 0.86

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