Fig. 1
From: Renal PET-imaging with 11C-metformin in a transgenic mouse model for chronic kidney disease
Expression of OCT2 is reduced in CKD mice. a–c Whole kidney tissue expression of a OCT1 mRNA, b OCT2 mRNA, and c MATE1 mRNA (values are mean ± SEM, n = 8) (*P = 0.015). d–e Western blot for OCT2 protein (d) with a wildtype mouse as positive control (lane 1) and a OCT1/2 KO mouse as negative control (lane 2). The band (arrow) corresponding to the positive control in the Tg and WT mice is assumed to represent OCT2 protein abundance (e) (values are relative to total protein and represent mean ± SEM, n = 7) (*P = 0.026)