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Table 1 Patient characteristics and clinical presentation

From: A dual tracer 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT pilot study for detection of cardiac sarcoidosis

Methotrexate Age Sex Immunosuppressive therapy ECG/Holter ECHO MRI Extra-cardiac sarcoidosis site/biopsy JMHW criteria fulfilled? Major JMHW criteria Minor JMHW criteria
1 41 M Methotrexate 20 mg/weekly, prednisolone 7.5 mg/daily SR ND No Pulmonary/med. LN No None None
2 54 M None SR, PVC, RBBB Normal Yes, anterior late enhancement Pulmonary/clinical diagnosis No None Non-sustained VT, MRI with anterior late enhancement
3 45 F None SR, PVC, RBBB Anterior, septal and apical hypokinesia No (pacemaker) Kidney/kidney biopsy Yes Decreased LVEF Left ventricular hypokinesia, VT, perfusion defects on scintigraphy
4 46 F None SR, PVC Basal, lateral aneurism No (pacemaker) Pulmonary/bronchial biopsy Yes Decreased LVEF Inferoseptal aneurism, perfusion defect on 82Rb PET, VT
5 37 M None 3rd degree AV-block, ventricular escape rhythm Normal LVEF, borderline right ventricular hypertrophy Yes, septal late enhancement, thickening of the right ventricle Pulmonary/clinical diagnosis Yes 3rd degree AV-block MRI with delayed enhancement in the septum + thickening of the right ventricle
6 59 M None SR, inferior Q-wave Normal Yes, no significant findings Pulmonary/clinical diagnosis No None PVC, RBBB
7 65 M None SR, RBBB, PVC Normal No (claustrophobia) Pulmonary/med. LN No None PVC, RBBB
8 36 F None SR, PVC Normal No Pulmonary/splenic biopsy No None PVC
9 59 M None SR, 1st degree AV-block, ST-depression Dilated atrial cavities Yes, basal and posterior late enhancement None (sarcoidosis diagnosis withdrawn) No (sarcoidosis diagnosis withdrawn) Decreased LVEF Left ventricular hypokinesia, MRI with late enhancement
10 60 F None SR Discrete aortal insufficiency No (pacemaker) Skin/dermal biopsy No 3rd degree AV-block VT
11 64 M Prednisolone 5 mg/daily SR Global hypokinesia Yes, no significant findings Pulmonary/cervical LN No Decreased LVEF PVC
12 51 F None Pacemaker rhythm Normal No (pacemaker) None (sarcoidosis diagnosis withdrawn) No 3rd degree AV-block  
13 33 M None SR, ST-depressions in V5-V6 Global hypokinesia Yes, dilated ventricles, no late enhancement None (sarcoidosis diagnosis withdrawn) No Advanced 2nd degree AV-block, depressed LVEF VT
14 58 M Methotrexate 10 mg/weekly SR Normal Yes, normal Pulmonary/med. LN No   
15 67 M Prednisolone 5 mg/daily Atrial flutter Discrete hypertrophia, normal LVEF No Multiorgan/dermal biopsy No   
16 46 F Methotrexate 5 mg/weekly SR Normal No Pulmonary/med. LN No   
17 39 M None SR Normal Yes, normal Pulmonary/clinical diagnosis No   
18 64 M None SR, LBBB Discrete hypokinesia No (nephropathy) Pulmonary/skin No Decreased LVEF Discrete hypokinesia of the septum
19 66 M None SR Normal No Pulmonary/bronchial biopsy No   
  1. Abbreviations: DE-MR delayed enhancement magnetic resonance, ECG electrocardiogram, ECHO echocardiography, EF ejection fraction, FEV1 forced expiratory volume, HR-CT high-resolution computed tomography, JMHW Japanese Ministry of Health and Welfare, LV left ventricle, LBBB left bundle branch block, med. LN mediastinal lymph node, PVC premature ventricular contractions, RBBB right bundle branch block, SR sinus rhytm, VT ventricular tachycardia