Table 1 Patient characteristics and clinical presentation
Methotrexate | Age | Sex | Immunosuppressive therapy | ECG/Holter | ECHO | MRI | Extra-cardiac sarcoidosis site/biopsy | JMHW criteria fulfilled? | Major JMHW criteria | Minor JMHW criteria |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 41 | M | Methotrexate 20 mg/weekly, prednisolone 7.5 mg/daily | SR | ND | No | Pulmonary/med. LN | No | None | None |
2 | 54 | M | None | SR, PVC, RBBB | Normal | Yes, anterior late enhancement | Pulmonary/clinical diagnosis | No | None | Non-sustained VT, MRI with anterior late enhancement |
3 | 45 | F | None | SR, PVC, RBBB | Anterior, septal and apical hypokinesia | No (pacemaker) | Kidney/kidney biopsy | Yes | Decreased LVEF | Left ventricular hypokinesia, VT, perfusion defects on scintigraphy |
4 | 46 | F | None | SR, PVC | Basal, lateral aneurism | No (pacemaker) | Pulmonary/bronchial biopsy | Yes | Decreased LVEF | Inferoseptal aneurism, perfusion defect on 82Rb PET, VT |
5 | 37 | M | None | 3rd degree AV-block, ventricular escape rhythm | Normal LVEF, borderline right ventricular hypertrophy | Yes, septal late enhancement, thickening of the right ventricle | Pulmonary/clinical diagnosis | Yes | 3rd degree AV-block | MRI with delayed enhancement in the septum + thickening of the right ventricle |
6 | 59 | M | None | SR, inferior Q-wave | Normal | Yes, no significant findings | Pulmonary/clinical diagnosis | No | None | PVC, RBBB |
7 | 65 | M | None | SR, RBBB, PVC | Normal | No (claustrophobia) | Pulmonary/med. LN | No | None | PVC, RBBB |
8 | 36 | F | None | SR, PVC | Normal | No | Pulmonary/splenic biopsy | No | None | PVC |
9 | 59 | M | None | SR, 1st degree AV-block, ST-depression | Dilated atrial cavities | Yes, basal and posterior late enhancement | None (sarcoidosis diagnosis withdrawn) | No (sarcoidosis diagnosis withdrawn) | Decreased LVEF | Left ventricular hypokinesia, MRI with late enhancement |
10 | 60 | F | None | SR | Discrete aortal insufficiency | No (pacemaker) | Skin/dermal biopsy | No | 3rd degree AV-block | VT |
11 | 64 | M | Prednisolone 5 mg/daily | SR | Global hypokinesia | Yes, no significant findings | Pulmonary/cervical LN | No | Decreased LVEF | PVC |
12 | 51 | F | None | Pacemaker rhythm | Normal | No (pacemaker) | None (sarcoidosis diagnosis withdrawn) | No | 3rd degree AV-block | |
13 | 33 | M | None | SR, ST-depressions in V5-V6 | Global hypokinesia | Yes, dilated ventricles, no late enhancement | None (sarcoidosis diagnosis withdrawn) | No | Advanced 2nd degree AV-block, depressed LVEF | VT |
14 | 58 | M | Methotrexate 10 mg/weekly | SR | Normal | Yes, normal | Pulmonary/med. LN | No | ||
15 | 67 | M | Prednisolone 5 mg/daily | Atrial flutter | Discrete hypertrophia, normal LVEF | No | Multiorgan/dermal biopsy | No | ||
16 | 46 | F | Methotrexate 5 mg/weekly | SR | Normal | No | Pulmonary/med. LN | No | ||
17 | 39 | M | None | SR | Normal | Yes, normal | Pulmonary/clinical diagnosis | No | ||
18 | 64 | M | None | SR, LBBB | Discrete hypokinesia | No (nephropathy) | Pulmonary/skin | No | Decreased LVEF | Discrete hypokinesia of the septum |
19 | 66 | M | None | SR | Normal | No | Pulmonary/bronchial biopsy | No |