Table 2 Absorbed doses (mGy/MBq) obtained by using the TIACs of the considered organs and respective standard deviations (SD)
From: 177Lu-OPS201 targeting somatostatin receptors: in vivo biodistribution and dosimetry in a pig model
Target Organ | Pig 1 | Pig 2 | Pig 3 | Pig 4 | Pig 5 | Mean ± SD (n = 5) |
|---|---|---|---|---|---|---|
Adrenals | 6.82E−02 | 7.69E−02 | 6.12E−02 | 7.39E−02 | 6.69E−02 | 6.94E−02 ± 0.01 |
Brain | 5.80E−02 | 6.74E−02 | 5.24E−02 | 5.90E−02 | 5.88E−02 | 5.91E−02 ± 0.01 |
Breasts | 5.59E−02 | 6.74E−02 | 5.14E−02 | 5.87E−02 | 5.66E−02 | 5.80E−02 ± 0.01 |
Gallbladder wall | 6.61E−02 | 7.55E−02 | 5.91E−02 | 7.08E−02 | 6.61E−02 | 6.75E−02 ± 0.01 |
LLI wall | 6.06E−02 | 7.10E−02 | 5.49E−02 | 6.55E−02 | 6.10E−02 | 6.26E−02 ± 0.01 |
Small intestine | 6.20E−02 | 7.25E−02 | 5.65E−02 | 6.65E−02 | 6.21E−02 | 6.39E−02 ± 0.01 |
Stomach wall | 6.13E−02 | 7.23E−02 | 5.61E−02 | 6.55E−02 | 6.13E−02 | 6.33E−02 ± 0.01 |
ULI wall | 6.19E−02 | 7.24E−02 | 5.64E−02 | 6.62E−02 | 6.20E−02 | 6.38E−02 ± 0.01 |
Heart wall | 1.10E−01 | 4.44E−01 | 9.35E−02 | 1.38E−01 | 1.23E−01 | 1.82E−01 ± 0.15 |
Kidneysa | 2.71E+00 | 2.17E+00 | 2.55E+00 | 4.46E+00 | 1.76E+00 | 2.73E+00 ± 1.03 |
Liver | 2.37E−01 | 1.68E−01 | 1.27E−01 | 2.17E−01 | 2.64E−01 | 2.03E−01 ± 0.05 |
Lungs | 5.94E−02 | 7.10E−02 | 5.39E−02 | 6.19E−02 | 6.01E−02 | 6.13E−02 ± 0.01 |
Muscle | 5.89E−02 | 6.92E−02 | 5.36E−02 | 6.20E−02 | 5.93E−02 | 6.06E−02 ± 0.01 |
Ovaries | 6.10E−02 | 7.16E−02 | 5.54E−02 | 6.60E−02 | 6.14E−02 | 6.31E−02 ± 0.01 |
Pancreas | 6.57E−02 | 7.60E−02 | 5.95E−02 | 7.09E−02 | 6.51E−02 | 6.74E−02 ± 0.01 |
Red marrow | 2.17E−01 | 7.72E−02 | 1.05E−01 | 7.00E−02 | 2.25E−01 | 1.39E−01 ± 0.08 |
Osteogenic cells | 1.34E+00 | 3.75E−01 | 5.73E−01 | 2.76E−01 | 1.38E+00 | 7.89E−01 ± 0.53 |
Skin | 5.58E−02 | 6.62E−02 | 5.11E−02 | 5.85E−02 | 5.64E−02 | 5.76E−02 ± 0.01 |
Spleen | 6.48E−02 | 7.48E−02 | 5.95E−02 | 7.13E−02 | 6.34E−02 | 6.68E−02 ± 0.01 |
Testes | 5.73E−02 | 6.81E−02 | 5.24E−02 | 6.16E−02 | 5.79E−02 | 5.95E−02 ± 0.01 |
Thymus | 5.84E−02 | 7.21E−02 | 5.35E−02 | 6.12E−02 | 5.92E−02 | 6.09E−02 ± 0.01 |
Thyroid | 5.85E−02 | 6.91E−02 | 5.34E−02 | 6.04E−02 | 5.92E−02 | 6.01E−02 ± 0.01 |
Urinary bladder wall | 2.44E−01 | 1.58E−01 | 5.78E−02 | 1.15E+00 | 1.64E−01 | 3.55E−01 ± 0.45 |
Uterus | 6.13E−02 | 7.19E−02 | 5.53E−02 | 6.96E−02 | 6.14E−02 | 6.39E−02 ± 0.01 |
Total body | 1.02E−01 | 8.76E−02 | 7.64E−02 | 8.87E−02 | 9.98E−02 | 9.09E−02 ± 0.01 |