Fig. 3
From: Impact of attenuation correction on clinical [18F]FDG brain PET in combined PET/MRI
Comparison of different attenuation correction approaches in FDG brain PET/MRI. a Relative FDG uptake comparison by statistical parametric mapping between PETPseudoCT/BoneDixon/Dixon vs. PETCTderived from the 13 patients investigated (note: PETBoneDixon was available in seven patients only). Midsagittal and lateral projections: significance level of p < 0.001; T value >3.9 (T > 5.2 for PETBoneDixon due to lower sample size). Relative FDG uptake was significantly lower in PETDixon/BoneDixon as compared to PETCTderived in a widespread area covering occipital, parietotemporal, and parieto-occipital cortices as well as the cerebellum. FDG uptake was significantly higher in PETPseudoCT as compared to PETCTderived in more restricted areas, including the primary and parietotemporal cortices as well as the cerebellum. b Mean images across all patients for the different attenuation correction approaches (after spatial normalization)