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Table 1 Biodistribution of [18F]Pyricoxib in control (left) and treated (right) HCA-7 tumor-bearing NIH-III mice (n = 4)

From: PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model

 

[18F]Pyricoxib

[18F]Pyricoxib + 2 mg celecoxib

Organ

  

 Blood

 0.65 ± 0.12

 0.98 ± 0.09

 Heart

 2.52 ± 0.54

 5.70 ± 1.58

 Lung

 3.75 ± 0.66

 52.26 ± 43.08

 Liver

 17.13 ± 1.22

 25.47 ± 2.44

 Kidneys

 4.38 ± 1.01

 8.40 ± 0.77

 Spleen

 1.24 ± 0.33

 2.72 ± 0.65

 Stomach

 1.08 ± 0.29

 3.96 ± 2.73

 Duodenum

 4.59 ± 0.73

 5.18 ± 1.31

 Intestine (small)

 8.08 ± 2.33

 6.66 ± 1.95

 Intestine (large)

 4.21 ± 1.74

 3.48 ± 0.80

 Pancreas

 3.92 ± 1.39

 7.22 ± 2.87

 Bone

 0.67 ± 0.19

 1.05 ± 0.16

 Ovaries

 8.22 ± 1.27

 4.97 ± 2.84

 Brain

 1.74 ± 0.51

 3.79 ± 0.56

 Fat

 12.67 ± 5.45

 5.80 ± 3.84

 Muscle

 1.42 ± 0.54

 1.59 ± 0.64

 HCA-7 tumor

 2.12 ± 0.53

 1.04 ± 0.30**

 Tumor/muscle

 1.81 ± 1.04

 0.70 ± 0.19

 Tumor/blood

 3.39 ± 0.55

 1.09 ± 0.41

  1. Data are displayed as means ± SD %ID/g after 60 min p.i
  2. **P < 0.05