Skip to main content

Advertisement

Table 1 Biodistribution of [18F]Pyricoxib in control (left) and treated (right) HCA-7 tumor-bearing NIH-III mice (n = 4)

From: PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model

  [18F]Pyricoxib [18F]Pyricoxib + 2 mg celecoxib
Organ   
 Blood  0.65 ± 0.12  0.98 ± 0.09
 Heart  2.52 ± 0.54  5.70 ± 1.58
 Lung  3.75 ± 0.66  52.26 ± 43.08
 Liver  17.13 ± 1.22  25.47 ± 2.44
 Kidneys  4.38 ± 1.01  8.40 ± 0.77
 Spleen  1.24 ± 0.33  2.72 ± 0.65
 Stomach  1.08 ± 0.29  3.96 ± 2.73
 Duodenum  4.59 ± 0.73  5.18 ± 1.31
 Intestine (small)  8.08 ± 2.33  6.66 ± 1.95
 Intestine (large)  4.21 ± 1.74  3.48 ± 0.80
 Pancreas  3.92 ± 1.39  7.22 ± 2.87
 Bone  0.67 ± 0.19  1.05 ± 0.16
 Ovaries  8.22 ± 1.27  4.97 ± 2.84
 Brain  1.74 ± 0.51  3.79 ± 0.56
 Fat  12.67 ± 5.45  5.80 ± 3.84
 Muscle  1.42 ± 0.54  1.59 ± 0.64
 HCA-7 tumor  2.12 ± 0.53  1.04 ± 0.30**
 Tumor/muscle  1.81 ± 1.04  0.70 ± 0.19
 Tumor/blood  3.39 ± 0.55  1.09 ± 0.41
  1. Data are displayed as means ± SD %ID/g after 60 min p.i
  2. **P < 0.05