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Table 3 Biodistribution of 177Lu-DOTANOC (5 MBq/2.5 nmol) in AR42J tumor-bearing female nude mice, expressed in percentage of total injected activity per gram tissue (% IA/g)

From: Preclinical in vivo application of 152Tb-DOTANOC: a radiolanthanide for PET imaging

  177Lu-DOTANOC
  30 min p.i. 2 h p.i. 5 h p.i. 16 h p.i. 22 h p.i.
Blood 2.52 ± 0.65 0.09 ± 0.01 0.06 ± 0.01 0.07 ± 0.01 0.03 ± 0.00
Heart 1.34 ± 0.35 0.08 ± 0.01 0.07 ± 0.01 0.07 ± 0.01 0.03 ± 0.00
Lung 3.04 ± 0.47 0.45 ± 0.03 0.41 ± 0.04 0.27 ± 0.05 0.21 ± 0.03
Spleen 0.77 ± 0.03 0.15 ± 0.01 0.18 ± 0.02 0.13 ± 0.04 0.09 ± 0.01
Kidneys 13.0 ± 1.85 7.67 ± 0.51 9.10 ± 1.66 6.13 ± 1.63 4.80 ± 0.19
Adrenals 1.38 ± 0.32 0.28 ± 0.14 0.37 ± 0.05 0.51 ± 0.40 0.42 ± 0.18
Stomach 1.95 ± 0.23 1.14 ± 0.04 1.21 ± 0.55 0.68 ± 0.09 0.60 ± 0.22
Pancreas 1.99 ± 0.07 1.09 ± 0.17 0.88 ± 0.11 0.34 ± 0.05 0.25 ± 0.03
Intestines 0.94 ± 0.12 0.25 ± 0.04 0.25 ± 0.03 0.16 ± 0.01 0.13 ± 0.03
Liver 1.43 ± 0.17 0.52 ± 0.04 0.53 ± 0.10 0.27 ± 0.05 0.20 ± 0.02
Muscle 0.48 ± 0.16 0.02 ± 0.00 0.02 ± 0.01 0.03 ± 0.00 0.01 ± 0.00
Bone 1.13 ± 0.26 0.17 ± 0.01 0.12 ± 0.02 0.12 ± 0.05 0.08 ± 0.01
Brain 0.06 ± 0.01 0.01 ± 0.00 0.02 ± 0.00 0.02 ± 0.01 0.01 ± 0.00
AR42J tumor 9.02 ± 0.33 8.32 ± 0.47 8.45 ± 1.04 5.48 ± 0.98 4.51 ± 0.37
Tumor-to-blood 3.76 ± 1.05 96.6 ± 8.79 137 ± 15.3 80.0 ± 8.30 180 ± 17.5
Tumor-to-liver 6.39 ± 0.89 16.1 ± 1.34 16.2 ± 2.10 21.0 ± 2.68 23.0 ± 2.96
Tumor-to-kidney 0.71 ± 0.11 1.09 ± 0.06 0.94 ± 0.16 0.93 ± 0.19 0.94 ± 0.02
  1. Values shown represent the mean ± S.D. of data from three animals (n = 3) per cohort