EJNMMI Research

Table 3 Biodistribution of ¹⁷⁷Lu-DOTANOC (5 MBq/2.5 nmol) in AR42J tumor-bearing female nude mice, expressed in percentage of total injected activity per gram tissue (% IA/g)

From: Preclinical in vivo application of ¹⁵²Tb-DOTANOC: a radiolanthanide for PET imaging

	¹⁷⁷Lu-DOTANOC
	30 min p.i.	2 h p.i.	5 h p.i.	16 h p.i.	22 h p.i.
Blood	2.52 ± 0.65	0.09 ± 0.01	0.06 ± 0.01	0.07 ± 0.01	0.03 ± 0.00
Heart	1.34 ± 0.35	0.08 ± 0.01	0.07 ± 0.01	0.07 ± 0.01	0.03 ± 0.00
Lung	3.04 ± 0.47	0.45 ± 0.03	0.41 ± 0.04	0.27 ± 0.05	0.21 ± 0.03
Spleen	0.77 ± 0.03	0.15 ± 0.01	0.18 ± 0.02	0.13 ± 0.04	0.09 ± 0.01
Kidneys	13.0 ± 1.85	7.67 ± 0.51	9.10 ± 1.66	6.13 ± 1.63	4.80 ± 0.19
Adrenals	1.38 ± 0.32	0.28 ± 0.14	0.37 ± 0.05	0.51 ± 0.40	0.42 ± 0.18
Stomach	1.95 ± 0.23	1.14 ± 0.04	1.21 ± 0.55	0.68 ± 0.09	0.60 ± 0.22
Pancreas	1.99 ± 0.07	1.09 ± 0.17	0.88 ± 0.11	0.34 ± 0.05	0.25 ± 0.03
Intestines	0.94 ± 0.12	0.25 ± 0.04	0.25 ± 0.03	0.16 ± 0.01	0.13 ± 0.03
Liver	1.43 ± 0.17	0.52 ± 0.04	0.53 ± 0.10	0.27 ± 0.05	0.20 ± 0.02
Muscle	0.48 ± 0.16	0.02 ± 0.00	0.02 ± 0.01	0.03 ± 0.00	0.01 ± 0.00
Bone	1.13 ± 0.26	0.17 ± 0.01	0.12 ± 0.02	0.12 ± 0.05	0.08 ± 0.01
Brain	0.06 ± 0.01	0.01 ± 0.00	0.02 ± 0.00	0.02 ± 0.01	0.01 ± 0.00
AR42J tumor	9.02 ± 0.33	8.32 ± 0.47	8.45 ± 1.04	5.48 ± 0.98	4.51 ± 0.37
Tumor-to-blood	3.76 ± 1.05	96.6 ± 8.79	137 ± 15.3	80.0 ± 8.30	180 ± 17.5
Tumor-to-liver	6.39 ± 0.89	16.1 ± 1.34	16.2 ± 2.10	21.0 ± 2.68	23.0 ± 2.96
Tumor-to-kidney	0.71 ± 0.11	1.09 ± 0.06	0.94 ± 0.16	0.93 ± 0.19	0.94 ± 0.02

Values shown represent the mean ± S.D. of data from three animals (n = 3) per cohort

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