Fig. 3
From: αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice
This figure shows coronal, axial, and sagittal views from CT (left), fused microSPECT/CT (middle), and SPECT (right) of αVβ3 integrin imaging, respectively. MicroSPECT/CT allows imaging of 99mTc-maraciclatide uptake (red arrow) into atherosclerotic plaques of ApoE−/− mouse. a CT images, SPECT/CT overlay images, and SPECT images obtained in an ApoE−/− mouse. b CT images, SPECT/CT overlay images, and SPECT images obtained in a C57BL/6 control mouse. c CT images, SPECT/CT overlay images, and SPECT images obtained in an ApoE−/− mouse who received the blocking peptide. Animals were kept under gas anesthesia (1–3 % isoflurane in O2 at a flow rate of 2 L/min). SPECT was performed 90 min after injection of about 52 MBq of 99mTc-maraciclatide. Total acquisition time was 30 min. The focal thyroid free-99mTc uptake is marked by an asterisk. LV left ventricle, AA aortic arch, CPV counts per voxel