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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Angiotensin II increases gene expression after selective intra-arterial adenovirus delivery in a rabbit model assessed using in vivo SSTR2-based reporter imaging

Fig. 5

Ex vivo analysis of 111In-octreotide biodistribution in VX2 tumors after adenoviral infection. a Graph showing significantly higher uptake in tumors infected with AII + Ad-CMV-HA-SSTR2 compared to tumors infected with control Ad-CMV-GFP (*p < 0.004, n = 4) and Ad-CMV-HA-SSTR2 (*p < 0.002, n = 6). The ex vivo %ID/g of Ad-CMV-HA-SSTR2 was also significantly higher compared to that of control Ad-CMV-GFP (p = 0.015). b Graph showing ex vivo organs and tumor biodistribution of 111In-octreotide in rabbits bearing VX2 tumors infected in vivo with AII + Ad-CMV-HA-SSTR2, Ad-CMV-HA-SSTR2, or control virus. Increased uptake was seen in tumors infected with AII + Ad-CMV-HA-SSTR2 or Ad-CMV-HA-SSTR2 as compared to tumors infected with control Ad-CMV-GFP (*p < 0.015, n = 4), which was also found by western blot analysis of HA-SSTR2 in tumors (inset)

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