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Fig. 4 | EJNMMI Research

Fig. 4

From: Angiotensin II increases gene expression after selective intra-arterial adenovirus delivery in a rabbit model assessed using in vivo SSTR2-based reporter imaging

Fig. 4

γ-Camera imaging data of VX2 tumors in rabbits. Representative gamma camera planar images of VX2 tumors (a) infected in vivo by IA administration of AII + Ad-CMV-HA-SSTR2 and Ad-CMV-HA-SSTR2 and (b) infected in vivo by IA infusion of Ad-CMV-GFP control and Ad-CMV-HA-SSTR2 show increased 111In-octreotide uptake in tumors infected with AII + Ad-CMV-HA-SSTR2 compared to infection with Ad-CMV-HA-SSTR2 and the control Ad-CMV-GFP. c 111In-octreotide biodistribution in tumors normalized to tumor weight (%ID/g) calculated with (black bars) and without (gray bars) necrosis using in vivo imaging from gamma camera and CT imaging. Uptake was higher in tumors infected with AII + Ad-CMV-HA-SSTR2 (n = 6) compared to control Ad-CMV-GFP (*p < 0.01, n = 4) and Ad-CMV-HA-SSTR2 (*p < 0.01, n = 6). The %ID/g without necrosis was significantly higher than the %ID/g with necrosis in tumors infected with AII + Ad-CMV-HA-SSTR2 (#p < 0.004, n = 6) and Ad-CMV-HA-SSTR2 (#p < 0.006, n = 6)

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