Radiolabel | Antibody | AUCtumour | AUCblood | AUCliver | AUCkidney | T/La | T/Kb | T/Bc |
---|---|---|---|---|---|---|---|---|
90Y-CHX-A" DTPA- | Wild type | 2849 | 1276 | 498 | 636 | 5.7 | 4.5 | 2.2 |
H435A | 2168 | 964 | 514 | 561 | 4.2 | 3.9 | 2.3 | |
I253A | 1541 | 1126 | 738 | 633 | 2.1 | 2.4 | 1.4 | |
H310A | 1506 | 559 | 676 | 482 | 2.2 | 3.1 | 2.7 | |
I253A/H310A | 1037 | 418 | 1037 | 412 | 1.0 | 2.5 | 2.5 | |
177Lu-CHX-A" DTPA- | Wild type | 5203 | 1709 | 833 | 1265 | 6.3 | 4.1 | 3.1 |
H435A | 4076 | 1235 | 835 | 932 | 4.9 | 4.4 | 3.3 | |
I253A | 3514 | 1362 | 1189 | 1029 | 3.0 | 3.4 | 2.6 | |
H310A | 2400 | 783 | 1104 | 774 | 2.2 | 3.1 | 3.1 | |
I253A/H310A | 2699 | 453 | 1421 | 539 | 1.9 | 5.0 | 6.0 | |
131I- | Wild type | 2739 | 2085 | 560 | 659 | 4.9 | 4.2 | 1.3 |
H435A | 679 | 516 | 129 | 175 | 5.2 | 3.9 | 1.3 | |
I253A | 568 | 516 | 141 | 159 | 4.0 | 3.6 | 1.1 | |
H310A | 655 | 439 | 118 | 125 | 5.5 | 5.2 | 1.5 | |
I253A/H310A | 602 | 422 | 107 | 120 | 5.6 | 5.0 | 1.4 |