Table 2 Dissociation constants (K d), apparent number of binding sites per cells (B max), and serum half-life of DOTA-PEG4-BN conjugates
Peptide conjugates | K d/nM | B max (binding sites/cell) *105 | Half-life/h |
|---|---|---|---|
BN1 | 3.30 ± 0.90 | 2.45 ± 0.73 | 16.1 |
BN2 | 4.27 ± 1.28 | 4.10 ± 1.23 | 20.9 |
BN3 | >1000 | ND | 40.7 |
BN4 | 4.97 ± 1.40 | 5.54 ± 1.56 | 224.1 |
BN5 | 10.89 ± 2.71 | 1.56 ± 0.39 | 354.2 |
BN6 | 3.90 ± 1.15 | 5.89 ± 1.74 | 208.3 |
BN7 | 6.36 ± 1.74 | 5.32 ± 1.46 | 18.7 |
BN8 | 5.91 ± 1.77 | 3.52 ± 1.03 | 414.1 |