Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors

EJNMMI Research

Table 1 Peptide conjugates with their corresponding peptide sequence, retention time (R _t), molecular weight (MW), and LC-MS data. All peptides contain DOTA-PEG4 on the N-terminus

Peptide conjugates	Peptide sequence	R _t/min	M_W/u.m.a.	[M + 2H⁺]/2
BN1	-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂	12.91	1595	797.4
BN2	-Gln-Trp-Ala-Val-Gly-His-Cha-Nle-NH₂	13.66	1630	817.6
BN3	-Gln-Trp-Ala-Val-Gly-His-Cha-Nle-Glu-NH₂	13.55	1759	880.7
BN4	-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH₂	12.56	1636	819.3
BN5	-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH₂	12.46	1649	825.4
BN6	-DPhe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH₂	13.19	1783	891.4
BN7	-DPhe-Gln-Trp-Ala-Val-Gly-His-Cha-Nle-NH₂	14.35	1780	891.5
BN8	-DPhe-Gln-Trp-Ala-Val-NMeGly-His-Sta-Leu-NH₂	13.13	1798	900.3