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Table 6 Histological evaluation of renal radiation injury in mice injected with 161Tb-folate or 177Lu-folate, indicated with partial scores for glomeruli, tubules, and interstitium

From: Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of 161Tb-folate and 177Lu-folate

  Control 161Tb-folate 177Lu-folate
Group Aa(n = 9) Group B: 10 MBq Group C: 20 MBq Group D: 30 MBq Group E: 10 MBq Group F: 20 MBq Group G:30 MBq
(n = 5)a (n = 5)a (n = 2)b (n = 5)a (n = 4)a (n = 5)b
Glomeruli 0 1.1 3.4 5.0 2.0 3.8 5.0
Tubules 0 0.9 2.4 4.5 1.5 3.3 4.2
Interstitium 0 0.4 1.8 4.0 0.4 3.3 4.6
Cumulative score 0 2.4 7.6 13.5 3.9 10.4 13.8
Final score 0 1 3 4 2 3 4
  1. The sum of the partial scores determined the cumulative scores, which were then converted to the final score as a measure for the different degrees of renal injury
  2. aMice euthanized in Week 34
  3. bMice euthanized between Weeks 15 and 26