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EJNMMI Research

Table 1 Summary of radiosynthesis

From: Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

 

Radiochemical yieldab (%)

Average synthesis time (min)

Specific activityac (GBq/mol)

Radiochemical purityc (%)

[11C]TASP0390136

10.1 ± 3.1

29

95 ± 23

>98

[11C]TASP0410457

1.7 ± 0.3

29

104 ± 7

>98

[11C]TASP0434988

15.5 ± 4.6

29

111 ± 16

>98

  1. aMean ± S.E.M., n = 3–8
  2. bBased on [11C]CO2 obtained by bombardment with decay-uncorrected at the end of synthesis (EOS)
  3. cData at EOS
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