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EJNMMI Research
Fig. 6 | EJNMMI Research

Fig. 6

From: Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Fig. 6

In vivo PET in anesthetized rhesus monkeys with acquisition of an arterial input function. a–c Representative plasma TAC (closed circles) and metabolite-corrected arterial input function (open circles) in a monkey (a), a representative radio-HPLC chromatogram of the protein-precipitated monkey plasma at 30 min after an administration of [11C]TASP0410457 (b) and time course of changes in the ratio of unmetabolized [11C]TASP0410457 in plasma (c; mean ± S.E.M, n = 3). d TACs in the striatum (circles) and pons-medulla (triangles) at baseline (closed symbols) and after pretreatment with 3 mg/kg of ciproxifan (open symbols) obtained in a single monkey. e Lassen plot for determination of the occupancy of H3Rs by ciproxifan. A circle in the Lassen plot denotes a value in each ROI, and a solid line represents regression

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