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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Fig. 5

In vivo PET in a conscious rhesus monkey. a–e Average horizontal PET images at 30–90 min after the intravenous administration of [11C]TASP0410457 (top) and [11C]TASP0434988 (bottom) at baseline (a, c) and after pretreatment with 1 mg/kg of unlabelled TASP0410457 (b) or TASP0434988 (d), along with co-registered MR images of the monkey brain (e). f–i TACs for [11C]TASP0410457 (top) and [11C]TASP0434988 (bottom) in the anterior cingulate cortex (closed circles), striatum (open circles), hippocampus (closed triangles), cerebellum (open triangles), and pons-medulla (squares) at baseline (left) and after pretreatment with 1 mg/kg of unlabelled compound (left)

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