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EJNMMI Research
Fig. 4 | EJNMMI Research

Fig. 4

From: Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Fig. 4

a–f: TACs for [11C]TASP0410457 (top), [11C]TASP0434988 (middle), and [11C]TASP0390136 (bottom) in the rat striatum (circles), hippocampus (rhombi), and cerebellum (triangles) at baseline (a–c) and after pretreatment with 10 mg/kg of thioperamide (d–f). g–i Temporal changes of specifically bound [11C]TASP0410457 (g), [11C]TASP0434988 (h), and [11C]TASP0390136 (i) in the striatum (circles) and hippocampus (rhombi) determined as ratios in SUVs between the target region and the cerebellum. Data are mean ± S.E.M (n = 3–5)

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