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Fig. 2 | EJNMMI Research

Fig. 2

From: Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Fig. 2

Pharmacokinetics of non-radiolabelled compounds in the rat brain. a–f The concentrations of TASP0410457 (a), TASP0434988 (b), TASP0390136 (c), TASP0390174 (d), TASP0410426 (e), and TASP0410427 (f) in the forebrain (closed circles) and cerebellum (open circles) were determined by ex vivo LC-MS/MS after the intravenous administration of 10 μg/kg of the compound in rats. The absence of symbols at 60 or 120 min in the plots indicates that the concentration measures were below the lower limit of quantification. Data are mean ± S.E.M (n = 3)

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