Table 1 Patient characteristics
From: Effects of erlotinib therapy on [11C]erlotinib uptake in EGFR mutated, advanced NSCLC
Number | Gender, age (years) | EGFR mutation (TKI sensitivity) | Response to erlotiniba | [11C]Erlotinib PET scans | Condition | Arterial sampling | Venous sampling | [15O]H2O PET scans | Remarks |
|---|---|---|---|---|---|---|---|---|---|
Change in V T b | Time interval to second scan (days) | ||||||||
1 | F | exon19 (p.delE746-A750) and exon20 (T790M) | PD | First scan | E+ | Yes | Yes | Yes | Ā |
60 | (sensitiveā+āresistant) | ā | Second scan | Eā | NA | NA | NA | Synthesis of [11C]erlotinib failed quality check | |
7 | |||||||||
2 | F | exon19 (p.delE746-A750) | CR | First scan | Eā | Yes | Yes | Yes | Ā |
82 | (sensitive) | ā52Ā % | Second scan | E+ | Yes | NA | Yes | No venous sampling due to clogging of the venous cannula | |
14 | |||||||||
3 | M | exon18 (p.G719S and p.E709A) | PR | First scan | Eā | Yes | Yes | Yes | Ā |
74 | ā17Ā % | Second scan | E+ | Yes | Yes | NA | Synthesis of [15O]H2O failed quality check | ||
13 | |||||||||
4 | M | exon21 (p.P848L) | ā | First scan | Eā | Yes | Yes | Yes | Ā |
66 | (resistant [24]) | ā43Ā % | Second scan | E+ | Yes | Yes | Yes | Ā | |
7 | |||||||||
5 | F | exon19 (p.delE746-T751) (sensitive) | PD | First scan | E+ | Yes | Yes | NA | Synthesis of [15O]H2O failed quality check |
61 | Ā | ā | Second scan | NA | NA | NA | NA | Yield of [11C]erlotinib synthesis too low | |
7 | |||||||||
6 | F | exon19 (p.delE746-A750) and exon20 (p.T790M) | Slow PD | First scan | E+ | Yes | Yes | Yes | Ā |
45 | (sensitiveā+āresistant) | ā47Ā % | Second scan | Eā | Yes | Yes | Yes | Ā | |
10 | |||||||||
7 | M | exon19 (p.E746-S752) and exon20 (p.T790M) | SD | First scan | Eā | NA | NA | NA | Aberrant arterial and venous blood sample values |
74 | (sensitiveā+āresistant) | ā | Aberrant [15O]H2O PET data | ||||||
Second scan | E+ | Yes | Yes | Yes | Ā | ||||
7 | |||||||||
8 | M | exon18 (p.G719S) and exon20 (p.S768I) | SD | First scan | Eā | Yes | Yes | Yes | Ā |
81 | ā58Ā % | Second scan | E+ | Yes | Yes | Yes | Ā | ||
7 | |||||||||
9 | F | exon19 (p.delE746-A750) | PR | First scan | Eā | Yes | Yes | Yes | Aberrant [15O]H2O PET data |
55 | (sensitive) | ā29Ā % | Second scan | E+ | Yes | Yes | Yes | Ā | |
10 | |||||||||
10 | F | exon19 (p.delL747-S752 and p.P753Q) and exon20 (p.T790M) | Slow PD | First scan | E+ | Yes | Yes | NA | No [15O]H2O synthesis |
71 | (sensitiveā+āresistant) | ā25Ā % | Second scan | Eā | Yes | Yes | NA | No [15O]H2O synthesis | |
14 | |||||||||
11 | F | exon21 (p.L861Q) | SD | First scan | Eā | Yes | Yes | Yes | Ā |
77 | (sensitive [28]) | ā39Ā % | Second scan | E+ | Yes | Yes | NA | No [15O]H2O synthesis | |
7 | |||||||||
12 | M | exon19 (p.delE746 S752) | PR | First scan | Eā | Yes | Yes | Yes | Ā |
70 | (sensitive) | ā | Second scan | NA | NA | NA | NA | Yield of [11C]erlotinib synthesis too low | |
7 | |||||||||
13 | F | exon21 (p.L858R) and exon20 (p.T790M) | Slow PD | First scan | Eā | Yes | Yes | Yes | Ā |
74 | (sensitiveā+āresistant) | ā40Ā % | Second scan | E+ | Yes | Yes | Yes | Ā | |
7 |