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EJNMMI Research
Fig. 6 | EJNMMI Research

Fig. 6

From: Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization

Fig. 6

Dual-spectral fluorescence molecular pathology allows simultaneous determination of HER2 and CAIX expression status. Detection of fluorescence on tumour sections obtained from mice 5 h p.i. of the combinations a 11A4-680 and B9-800, b 11A4-800 and R2-700 and c B9-800 and R2-700. The fluorescence detected with the odyssey scanner is depicted in green for channel 800 nm (IRDye800CW) and in red for channel 700 nm (IRDye680RD and IRDye700DX). H&E staining of the corresponding section is depicted, where an asterisk indicates necrotic area. d IHC on sections of tumour xenografts depicting expression of HER2 and CAIX

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