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EJNMMI Research
Fig. 4 | EJNMMI Research

Fig. 4

From: Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization

Fig. 4

Dual-spectral imaging with two tumour-specific VHHs allows simultaneous tumour molecular status determination in an invasive, mimicked intra-operative setting. a Five hours p.i. of 11A4-680 and B9-800 (left), 11A4-800 and R2-700 (middle) or B9-800 and R2-700 (right) mice were sacrificed by cervical dislocation and their skin removed to mimic image-guided surgery setting. b–d T/B ratios were calculated for tumours imaged in the mimicked intra-operative setting. Bars represent mean, n = 4 mice in groups 11A4-800 and R2-700 and B9-800 and 11A4-680, n = 6 mice in group B9-800 and R2-700. Statistical significance is indicated by * when p < 0.05 and *** when p < 0.0001

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