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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization

Fig. 2

Dual spectral molecular imaging using tumour-specific VHHs allows for simultaneous expression status determination of two different tumour markers, namely CAIX (targeted by VHH B9) and HER2 (targeted by VHH 11A4). Irrelevant VHH R2-700 was used as a negative control. Mice xenografted with MCF10DCIS cells were imaged in time upon injection of the following: a tumour-specific combination consisting of 11A4-680 and B9-800, b control combination consisting of 11A4-800 and R2-700 and c control combination consisting of B9-800 and R2-700. The observed yellow colour present in the overlays in each of the bottom panels originates from the overlay of green and red signals

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