X1 | X2 | X3 | X4 | Relative binding index | IC50 (μM) | |
---|---|---|---|---|---|---|
LXY1 | L | G | N | 1.00 ± 0.05 | 3.5 ± 0.4 | |
LXY4 | Phe(3,5-diF) | G | N | 1.36 ± 0.11 | 0.41 ± 0.03 | |
LXY5 | Phe(3,4,5-triF) | G | N | D-T | 1.45 ± 0.12 | ND |
LXY6 | Phe(3,5-diF) | G | N | W | 1.17 ± 0.08 | ND |
LXY7 | Phe(3,4,5-triF) | G | N | R | 1.62 ± 0.10 | 0.13 ± 0.012 |
LXY8 | L | G | N | D | 0.22 ± 0.03 | ND |
LXY9 | Phe(3,5-diF) | G | N | D-S | 1.44 ± 0.11 | ND |
LXY10 | L | G | D | G | 0.64 ± 0.05 | ND |
LXY11 | Phe(3,4-diF) | G | N | D-K | 1.01 ± 0.10 | ND |
LXY12 | Phe(3,4-diF) | G | N | S | 0.47 ± 0.05 | ND |
LXY13 | Phe(3,4,5-triF) | G | N | D | 0.57 ± 0.03 | ND |
LXY14 | Phe(3,4,5-triF) | G | N | D-S | 1.35 ± 0.09 | ND |
LXY15 | Phe(3,5-diF) | G | N | D-K | 1.31 ± 0.08 | ND |
LXY16 | Phe(3,5-diF) | G | N | S | 0.61 ± 0.05 | ND |
LXY17 | Phe(3,4-diF) | G | N | G | 0.65 ± 0.06 | ND |
LXY18 | Phe(3,4-diF) | G | N | W | 0.01 ± 0.008 | ND |
LXY19 | Phe(3,5-diF) | G | S | 0.84 ± 0.07 | ND | |
LXY20 | L | G | D-Thi | 0.15 ± 0.02 | ND | |
LXY21 | Phe(3,5-diF) | G | Y | 0.62 ± 0.04 | ND | |
LXY22 | L | G | R | 0.93 ± 0.1 | ND | |
LXY23 | L | G | Orn | W | 0.7 ± 0.06 | ND |
LXY29 | Phe(3,4-diF) | G | N | R | 1.59 ± 0.09 | ND |
LXY30 | Phe(3,5-diF) | G | N | R | 1.68 ± 0.10 | 0.08 ± 0.01 |
LXY32 | L | G | N | R | 0.94 ± 0.07 | ND |
LXY33 | OLeu1 | G | N | R | 0.81 ± 0.1 | ND |
LXY34 | N- [(3,4,5-triF)benzyl]Gly2 | G | N | R | 0.68 ± 0.06 | ND |
LXY36 | Phe(3,4,5-triF) | G | N | D-R | 1.39 ± 0.10 | ND |
LXY37 | L | G | N | D-R | 0.67 ± 0.06 | ND |
LXY38 | Phe(3,5-diF) | G | N | D-R | 0.69 ± 0.05 | ND |
LXY39 | Phe(3,5-diF) | Aoa3 | N | D-R | 1.09 ± 0.09 | ND |