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Fig. 6 | EJNMMI Research

Fig. 6

From: Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modeling

Fig. 6

Simulated rate of surface binding and internalization for 180-μg Ab doses of 124I- and 89Zr-J591. Surface binding decreases with time, but activity detected at tumor remains high due to internalized Ab-Ag. Differences in total observed tumor activity can be explained primarily by differences in the internalized portion of injected dose while surface binding curves remain nearly identical across radiolabels

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