Fig. 6From: Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modelingSimulated rate of surface binding and internalization for 180-μg Ab doses of 124I- and 89Zr-J591. Surface binding decreases with time, but activity detected at tumor remains high due to internalized Ab-Ag. Differences in total observed tumor activity can be explained primarily by differences in the internalized portion of injected dose while surface binding curves remain nearly identical across radiolabelsBack to article page