Fig. 5

Combining scVEGF/¹⁷⁷Lu with Doxil inhibits tumor growth more efficiently than single-agent treatment in orthotopic MDA231luc human breast carcinoma model in SCID mice. Effects of scVEGF/¹⁷⁷Lu+Doxil, scVEGF/¹⁷⁷Lu alone or Doxil (+ equivalent amounts of cold scVEGF-PEG-DOTA), relative to control tumors injected with equivalent amounts of cold scVEGF-PEG-DOTA conjugate alone. Growth curves for individual tumors were approximated as exponential and tumor doubling time was calculated for each tumor and the sets of data presented as watershed plots for each group. Average doubling time ±STD is indicated on the plot for each group