Table 5 Ratios between bone and soft tissue after 60 min p.i. of 177Lu-complexes in Wistar rats
From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
Bone/organ | [177Lu]citrate | [177Lu]BPAMD | [177Lu]BPAPD | [177Lu]BPPED | [177Lu]NO2APBP | [177Lu]DO2A(PBP)2 | [177Lu]DOTA(MBP)2 |
|---|---|---|---|---|---|---|---|
Blood | 18.7 | 135.6 | 95.1 | 92.9 | 45.8 | 3.6 | 3.8 |
Brain | 65.4 | 613.4 | 513.9 | 419.9 | 254.3 | 111.5 | 104.0 |
Pancreas | 8.2 | 136.4 | 104.9 | 181.6 | 56.7 | 14.5 | 18.0 |
Spleen | 5.8 | 68.2 | 85.7 | 41.0 | 66.0 | 14.2 | 10.4 |
Adrenal gland | 6.6 | 109.6 | 45.8 | 72.5 | 31.4 | 9.1 | 10.4 |
Kidneys | 2.9 | 14.0 | 10.3 | 14.9 | 7.1 | 2.7 | 3.8 |
Adipose tissue | 11.8 | 134.5 | 70.7 | 269.7 | 37.2 | 8.2 | 18.4 |
Muscle | 11.8 | 251.7 | 158.7 | 355.8 | 141.4 | 29.8 | 22.9 |
Heart | 4.7 | 210.1 | 158.7 | 141.1 | 89.0 | 8.2 | 8.6 |
Lung | 3.7 | 69.1 | 62.6 | 67.5 | 46.8 | 5.1 | 6.1 |
Thymus | 7.7 | 58.6 | 70.7 | 212.0 | 59.0 | 11.6 | 14.4 |
Harderian gland | 0.4 | 118.8 | 35.8 | 36.4 | 85.6 | 10.6 | 11.7 |
Liver | 4.0 | 127.5 | 105.4 | 42.3 | 87.0 | 8.6 | 7.8 |
Testes | 9.9 | 179.1 | 199.7 | 185.1 | 113.5 | 15.8 | 16.2 |