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Table 5 Ratios between bone and soft tissue after 60 min p.i. of 177Lu-complexes in Wistar rats

From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Bone/organ [177Lu]citrate [177Lu]BPAMD [177Lu]BPAPD [177Lu]BPPED [177Lu]NO2APBP [177Lu]DO2A(PBP)2 [177Lu]DOTA(MBP)2
Blood 18.7 135.6 95.1 92.9 45.8 3.6 3.8
Brain 65.4 613.4 513.9 419.9 254.3 111.5 104.0
Pancreas 8.2 136.4 104.9 181.6 56.7 14.5 18.0
Spleen 5.8 68.2 85.7 41.0 66.0 14.2 10.4
Adrenal gland 6.6 109.6 45.8 72.5 31.4 9.1 10.4
Kidneys 2.9 14.0 10.3 14.9 7.1 2.7 3.8
Adipose tissue 11.8 134.5 70.7 269.7 37.2 8.2 18.4
Muscle 11.8 251.7 158.7 355.8 141.4 29.8 22.9
Heart 4.7 210.1 158.7 141.1 89.0 8.2 8.6
Lung 3.7 69.1 62.6 67.5 46.8 5.1 6.1
Thymus 7.7 58.6 70.7 212.0 59.0 11.6 14.4
Harderian gland 0.4 118.8 35.8 36.4 85.6 10.6 11.7
Liver 4.0 127.5 105.4 42.3 87.0 8.6 7.8
Testes 9.9 179.1 199.7 185.1 113.5 15.8 16.2