Table 4 Ratios between bone and soft tissue after 5 min p.i. of 177Lu-complexes in Wistar rats
From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
Bone/organ | [177Lu]citrate | [177Lu]BPAMD | [177Lu]BPAPD | [177Lu]BPPED | [177Lu]NO2APBP | [177Lu]DO2A(PBP)2 | [177Lu]DOTA(MBP)2 |
|---|---|---|---|---|---|---|---|
Blood | n.d. | 3.7 | 4.1 | 3.2 | 1.3 | 0.6 | 0.6 |
Brain | n.d. | 83.9 | 68.5 | 104.0 | 66.8 | 23.4 | 17.7 |
Pancreas | n.d. | 10.8 | 2.1 | 11.2 | 9.9 | 2.9 | 3.4 |
Spleen | n.d. | 9.1 | 2.7 | 10.7 | 11.6 | 3.5 | 3.0 |
Adrenal gland | n.d. | 8.4 | 6.2 | 5.9 | 4.5 | 1.7 | 2.2 |
Kidneys | n.d. | 0.7 | 0.9 | 1.3 | 0.9 | 0.7 | 0.7 |
Adipose tissue | n.d. | 8.0 | 1.9 | 17.3 | 5.0 | 1.4 | 4.2 |
Muscle | n.d. | 17.7 | 4.4 | 17.3 | 12.7 | 4.3 | 4.7 |
Heart | n.d. | 9.3 | 9.5 | 8.0 | 8.6 | 1.6 | 1.6 |
Lung | n.d. | 5.5 | 5.6 | 5.5 | 5.3 | 1.1 | 1.1 |
Thymus | n.d. | 11.6 | 11.4 | 10.9 | 12.1 | 2.8 | 2.5 |
Harderian gland | n.d. | 9.3 | 9.3 | 10.4 | 7.6 | 2.2 | 2.1 |
Liver | n.d. | 12.9 | 8.8 | 8.7 | 9.2 | 2.0 | 2.0 |
Testes | n.d. | 13.4 | 12.2 | 11.6 | 8.3 | 8.8 | 7.7 |