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Table 4 Ratios between bone and soft tissue after 5 min p.i. of 177Lu-complexes in Wistar rats

From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Bone/organ [177Lu]citrate [177Lu]BPAMD [177Lu]BPAPD [177Lu]BPPED [177Lu]NO2APBP [177Lu]DO2A(PBP)2 [177Lu]DOTA(MBP)2
Blood n.d. 3.7 4.1 3.2 1.3 0.6 0.6
Brain n.d. 83.9 68.5 104.0 66.8 23.4 17.7
Pancreas n.d. 10.8 2.1 11.2 9.9 2.9 3.4
Spleen n.d. 9.1 2.7 10.7 11.6 3.5 3.0
Adrenal gland n.d. 8.4 6.2 5.9 4.5 1.7 2.2
Kidneys n.d. 0.7 0.9 1.3 0.9 0.7 0.7
Adipose tissue n.d. 8.0 1.9 17.3 5.0 1.4 4.2
Muscle n.d. 17.7 4.4 17.3 12.7 4.3 4.7
Heart n.d. 9.3 9.5 8.0 8.6 1.6 1.6
Lung n.d. 5.5 5.6 5.5 5.3 1.1 1.1
Thymus n.d. 11.6 11.4 10.9 12.1 2.8 2.5
Harderian gland n.d. 9.3 9.3 10.4 7.6 2.2 2.1
Liver n.d. 12.9 8.8 8.7 9.2 2.0 2.0
Testes n.d. 13.4 12.2 11.6 8.3 8.8 7.7
  1. n.d. data not determined