Table 3 Biodistribution of radioactivity after 8 days p.i. of 177Lu-complexes in Wistar rats
From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
Organ | [177Lu]citrate | [177Lu]BPAMD | [177Lu]BPAPD | [177Lu]BPPED | [177Lu]NO2APBP | [177Lu]DO2A(PBP)2 | [177Lu]DOTA(MBP)2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
Blood | n.d. | n.d. | 0.001 | 0.000 | n.d. | n.d. | 0.001 | 0.001 | n.d. | n.d. | n.d. | n.d. | 0.003 | 0.001 |
Brain | n.d. | n.d. | 0.004 | 0.001 | n.d. | n.d. | 0.014 | 0.021 | n.d. | n.d. | n.d. | n.d. | 0.018 | 0.007 |
Pancreas | n.d. | n.d. | 0.006 | 0.001 | n.d. | n.d. | 0.005 | 0.003 | n.d. | n.d. | n.d. | n.d. | 0.067 | 0.019 |
Spleen | n.d. | n.d. | 0.020 | 0.002 | n.d. | n.d. | 0.021 | 0.003 | n.d. | n.d. | n.d. | n.d. | 0.697 | 0.348 |
Adrenal gland | n.d. | n.d. | 0.009 | 0.006 | n.d. | n.d. | 0.033 | 0.011 | n.d. | n.d. | n.d. | n.d. | 0.166 | 0.063 |
Kidneys | n.d. | n.d. | 0.076 | 0.015 | n.d. | n.d. | 0.088 | 0.010 | n.d. | n.d. | n.d. | n.d. | 0.369 | 0.075 |
Adipose tissue | n.d. | n.d. | 0.004 | 0.003 | n.d. | n.d. | 0.004 | 0.004 | n.d. | n.d. | n.d. | n.d. | 0.026 | 0.012 |
Muscle | n.d. | n.d. | 0.136 | 0.107 | n.d. | n.d. | 0.027 | 0.056 | n.d. | n.d. | n.d. | n.d. | 0.024 | 0.003 |
Heart | n.d. | n.d. | 0.006 | 0.001 | n.d. | n.d. | 0.008 | 0.001 | n.d. | n.d. | n.d. | n.d. | 0.099 | 0.024 |
Lung | n.d. | n.d. | 0.008 | 0.001 | n.d. | n.d. | 0.008 | 0.002 | n.d. | n.d. | n.d. | n.d. | 0.117 | 0.045 |
Thymus | n.d. | n.d. | 0.006 | 0.001 | n.d. | n.d. | 0.006 | 0.002 | n.d. | n.d. | n.d. | n.d. | 0.109 | 0.033 |
Harderian gland | n.d. | n.d. | 0.105 | 0.127 | n.d. | n.d. | 0.113 | 0.132 | n.d. | n.d. | n.d. | n.d. | 0.331 | 0.131 |
Liver | n.d. | n.d. | 0.025 | 0.002 | n.d. | n.d. | 0.027 | 0.003 | n.d. | n.d. | n.d. | n.d. | 0.470 | 0.078 |
Testes | n.d. | n.d. | 0.004 | 0.000 | n.d. | n.d. | 0.004 | 0.001 | n.d. | n.d. | n.d. | n.d. | 0.050 | 0.005 |
Femur | n.d. | n.d. | 5.039 | 0.453 | n.d. | n.d. | 5.197 | 0.435 | n.d. | n.d. | n.d. | n.d. | 7.340 | 1.009 |