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Table 3 Biodistribution of radioactivity after 8 days p.i. of 177Lu-complexes in Wistar rats

From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Organ [177Lu]citrate [177Lu]BPAMD [177Lu]BPAPD [177Lu]BPPED [177Lu]NO2APBP [177Lu]DO2A(PBP)2 [177Lu]DOTA(MBP)2
Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD
Blood n.d. n.d. 0.001 0.000 n.d. n.d. 0.001 0.001 n.d. n.d. n.d. n.d. 0.003 0.001
Brain n.d. n.d. 0.004 0.001 n.d. n.d. 0.014 0.021 n.d. n.d. n.d. n.d. 0.018 0.007
Pancreas n.d. n.d. 0.006 0.001 n.d. n.d. 0.005 0.003 n.d. n.d. n.d. n.d. 0.067 0.019
Spleen n.d. n.d. 0.020 0.002 n.d. n.d. 0.021 0.003 n.d. n.d. n.d. n.d. 0.697 0.348
Adrenal gland n.d. n.d. 0.009 0.006 n.d. n.d. 0.033 0.011 n.d. n.d. n.d. n.d. 0.166 0.063
Kidneys n.d. n.d. 0.076 0.015 n.d. n.d. 0.088 0.010 n.d. n.d. n.d. n.d. 0.369 0.075
Adipose tissue n.d. n.d. 0.004 0.003 n.d. n.d. 0.004 0.004 n.d. n.d. n.d. n.d. 0.026 0.012
Muscle n.d. n.d. 0.136 0.107 n.d. n.d. 0.027 0.056 n.d. n.d. n.d. n.d. 0.024 0.003
Heart n.d. n.d. 0.006 0.001 n.d. n.d. 0.008 0.001 n.d. n.d. n.d. n.d. 0.099 0.024
Lung n.d. n.d. 0.008 0.001 n.d. n.d. 0.008 0.002 n.d. n.d. n.d. n.d. 0.117 0.045
Thymus n.d. n.d. 0.006 0.001 n.d. n.d. 0.006 0.002 n.d. n.d. n.d. n.d. 0.109 0.033
Harderian gland n.d. n.d. 0.105 0.127 n.d. n.d. 0.113 0.132 n.d. n.d. n.d. n.d. 0.331 0.131
Liver n.d. n.d. 0.025 0.002 n.d. n.d. 0.027 0.003 n.d. n.d. n.d. n.d. 0.470 0.078
Testes n.d. n.d. 0.004 0.000 n.d. n.d. 0.004 0.001 n.d. n.d. n.d. n.d. 0.050 0.005
Femur n.d. n.d. 5.039 0.453 n.d. n.d. 5.197 0.435 n.d. n.d. n.d. n.d. 7.340 1.009
  1. Data are expressed in SUV. Each value represents the mean (S.D.) for five animals. As an exception are the data in three decimal places to show also the very low values
  2. n.d. data not determined