From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
Organ | [177Lu]citrate | [177Lu]BPAMD | [177Lu]BPAPD | [177Lu]BPPED | [177Lu]NO2APBP | [177Lu]DO2A(PBP)2 | [177Lu]DOTA(MBP)2 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
Blood | 0.22 | 0.11 | 0.04 | 0.01 | 0.04 | 0.00 | 0.06 | 0.01 | 0.07 | 0.02 | 1.25 | 0.09 | 1.43 | 0.32 |
Brain | 0.06 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.04 | 0.01 | 0.05 | 0.01 |
Pancreas | 0.50 | 0.05 | 0.04 | 0.02 | 0.04 | 0.02 | 0.03 | 0.01 | 0.06 | 0.01 | 0.31 | 0.05 | 0.30 | 0.07 |
Spleen | 0.70 | 0.12 | 0.07 | 0.06 | 0.05 | 0.01 | 0.14 | 0.04 | 0.05 | 0.01 | 0.31 | 0.03 | 0.52 | 0.25 |
Adrenal gland | 0.62 | 0.05 | 0.04 | 0.04 | 0.09 | 0.06 | 0.08 | 0.12 | 0.11 | 0.05 | 0.49 | 0.09 | 0.52 | 0.20 |
Kidneys | 1.41 | 0.11 | 0.35 | 0.06 | 0.39 | 0.06 | 0.38 | 0.04 | 0.47 | 0.07 | 1.66 | 0.40 | 1.41 | 0.16 |
Adipose tissue | 0.35 | 0.03 | 0.04 | 0.02 | 0.06 | 0.02 | 0.02 | 0.01 | 0.09 | 0.03 | 0.55 | 0.12 | 0.29 | 0.16 |
Muscle | 0.35 | 0.02 | 0.02 | 0.01 | 0.03 | 0.02 | 0.02 | 0.00 | 0.02 | 0.01 | 0.15 | 0.01 | 0.24 | 0.06 |
Heart | 0.87 | 0.10 | 0.02 | 0.01 | 0.03 | 0.00 | 0.04 | 0.01 | 0.04 | 0.01 | 0.54 | 0.10 | 0.63 | 0.12 |
Lung | 1.13 | 0.13 | 0.07 | 0.01 | 0.06 | 0.00 | 0.08 | 0.02 | 0.07 | 0.01 | 0.89 | 0.12 | 0.89 | 0.13 |
Thymus | 0.53 | 0.09 | 0.08 | 0.04 | 0.06 | 0.02 | 0.03 | 0.01 | 0.06 | 0.01 | 0.39 | 0.05 | 0.37 | 0.10 |
Harderian gland | 9.62 | 5.62 | 0.04 | 0.01 | 0.11 | 0.11 | 0.16 | 0.08 | 0.06 | 0.01 | 0.42 | 0.05 | 0.46 | 0.09 |
Liver | 1.04 | 0.09 | 0.04 | 0.01 | 0.04 | 0.01 | 0.13 | 0.01 | 0.04 | 0.00 | 0.52 | 0.11 | 0.69 | 0.36 |
Testes | 0.42 | 0.03 | 0.03 | 0.01 | 0.02 | 0.01 | 0.03 | 0.00 | 0.03 | 0.01 | 0.28 | 0.03 | 0.33 | 0.04 |
Femur | 4.12 | 0.31 | 4.84 | 0.44 | 4.05 | 0.36 | 5.67 | 0.10 | 3.34 | 0.28 | 4.48 | 0.38 | 5.41 | 0.46 |