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Fig. 5 | EJNMMI Research

Fig. 5

From: Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis

Fig. 5

a In vitro autoradiograms of human carotid plaques with different scores under baseline (111In-DOTA-belatacept) and blockade condition (111In-DOTA-belatacept with excess unlabeled belatacept). Scale bar 3 mm. bd Relative specific binding of 111In-DOTA-belatacept determined by in vitro autoradiography. Samples were classified according to their score (0–1: n = 11; ≥2: n = 21); no (n = 11), few (n = 18, <50 cells), or many (n = 8, ≥50 cells) immune cells (macrophages and foam cells); no (n = 11), small (n = 17, <50 % plaque thickness, <25 % total cross-sectional area), or large (n = 9, ≥50 % plaque thickness, ≥25 % total cross-sectional area) lipid/necrotic core. ns non-significant, *p < 0.05

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