Fig. 5

SPECT/CT imaging with ¹¹¹In-17G1 reveals lung metastases. a Thoracic scan showing DPC-1 lesions in lungs (top): CT (left) and radiotracer uptake (middle) with fusion image (right). Numerous small lesions were visible with the 17G1 radiotracer by SPECT (lower left). Lesion contrast to background plotted as a function of nodule size (lower right). b Lung metastases visible (top left) at necropsy performed 1 week after the last SPECT/CT imaging session. Subset of metastases were dissected (top middle) and weighed to count remaining radioactivity; the radiotracer uptake correlates with weight of metastases (lower left), in line with SPECT/CT imaging data. DPC-1 cells in lung metastases (H&E, top right) express high PSMA levels (IHC, lower right) (×40).