Fig. 3

Specificity of prostate imaging with ¹¹¹In-17G1. a Tracer uptake in the prostate. Dogs #1 and #2 served as controls to establish a threshold for significance. ¹¹¹In-17G1 was injected prior to DPC-1 cells implantation and at 4.5 months of tumor growth (biopsy-proven between 6 and 8 weeks) along with ¹¹¹In-mouse IgGs at 4 months. b Representative SPECT/CT axial, sagittal, and coronal images of ¹¹¹In-17G1 uptake (top) in a large portion of the prostate of dog #5 and corresponding tumor foci mapped in sections from consecutive whole-mounted blocks (lower). c Example of SPECT/CT image with ¹¹¹In-17G1 uptake in the periphery of the prostate (left top), confirmed by mapping DPC-1 tumor foci at the capsule (lower panel), PSMA expression by IHC (middle top) and corresponding H&E staining (right top) ×20