Table 1 aHSCs biomarkers and corresponding ligands (*aHSC-targeted imaging studies)

Integrin αvβ3

cRGDfK

[35, 45, 47*, 57*]

cRGDyC

[46*]

RGD4C (ACDCRGDCFCG)

[32]

RGD10 (DGARYCRGDCFDG)

[33]

cRGDf-N(Me)V

[36]

Apt-αvβ3-1

[37]

(5'-GGGAGACAAGAAUAAACGCUCAAUUCAACGCUGUGAAGGGCUUAUACGAGCGGAUUACCCUUCGACAGGAGGCUCACAAAAGGC-3')

Apt-αvβ3-2

[38]

(5′-UUCAACGCUGUGAAGGGCUUAUACGAGCGGAUUACCC-3′)

Apt-αvβ3-3

[39]

(5′- AGTTCGZZZZAAGAAAZZAGCACACCGZZGACZZGZZZAGZGGCGGACCA-3′)

Z: 5-N-(benzylcarbox-yamide)-2′-deoxyuridine

Vimentin and desmin

N-acetylglucosamine (GlcNAc)

[64, 66, 67*]

VNTANST

[68]

M6P/IGF-IIR

M6P

[75]

Phosphonate, carboxylate, or malonate analogs of M6P

[80–83]

CVIR

C*GRGDSPC*

[96, 97]

C*GRGDSPK*

[98, 99]

PDGFR-β

C*SRNLIDC*

[105]

ANFLVWEIVRKKP

[109]

PDGF-BB^73–81

[110, 111]

(R*KIEIVRKKC*)

Apt-PDGFR-β

[113]

(5′-UGUCGUGGGGCAUCGAGUAAAUGCAAUUCGACA-3′)