Fig. 2

Shared transcript regulation between different day times of administration. The total number (no.) of significantly up- and down-regulated transcripts after 24 h following i.v. administration of 90 kBq ¹³¹I at 9:00, 12:00, and 15:00 is shown. Statistical comparison between exposure group(s) and control group(s) was made individually for each time of day (large circles), for pair-wise comparison between time points (oval shape between large circles), and over all time points (center circle). Large circles indicate the number of differentially regulated transcripts in a treated group compared with the control group at the respective time of day. Oval shapes between circles indicate the number of transcripts that were shared between two time points, i.e., transcripts that were differentially regulated in both treated groups compared with the two respective control groups. The center circle indicates the number of transcripts that were differentially regulated and shared among all time points, i.e., comparisons were performed between all three treated groups with their respective control groups. Please note that the diagram is not a classical Venn diagram, since the statistical population differs between each comparison analysis