Fig. 2

^99mTc-SER-4 NanoSPECT/CT imaging and biodistribution of Sn⁺ macrophages. C57Bl/6 wild-type (WT) mice were imaged a 0.5 h, b 1 h, c 3 h and d 6 h post injection with ^99mTc-SER-4. Arrows indicate uptake of tracer by Sn⁺ macrophages in the spleen (S), liver (L) and bone marrow (BM). After imaging, C57BL/6 wild-type (WT) mice were euthanized and tissues explanted, weighed and gamma counted. Maximum intensity projections are shown. e ^99mTc-SER-4 biodistributions at 1, 3 and 6 h post injection were expressed as percentage injected dose per gram of tissue (%ID/g). Error bars represent the standard error of the mean of n = 3